Description

n-Desmethyl Selegiline-D5, also known as Desmethyl Deprenyl-D5, is a deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on neuropharmacology and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the bioanalysis of selegiline and its metabolites in biological matrices like plasma and urine.
• Pharmacokinetic Studies: Enables accurate measurement of drug concentration-time profiles for selegiline and n-desmethylselegiline in clinical and preclinical research.
• Metabolic Pathway Investigation: Facilitates the study of selegiline's metabolic fate and the identification of its downstream metabolites.
• Method Development and Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Quality Control in Reference Material Production: Employed in the calibration and quality assurance of certified reference materials (CRMs) for selegiline.

Basic Information

Product Name	n-Desmethyl Selegiline-D5 / Desmethyl Deprenyl-D5
CAS No.	1217977-04-2
Molecular Formula	C12H10D5N
Molecular Weight	172.27 g/mol
Synonyms	(R)-(-)-N-(1-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine-D5; (R)-N-Desmethyl-Deprenyl-D5; (R)-N-Desmethyl-Selegiline-D5; D5-Labeled N-Desmethylselegiline; Deuterated Desmethylselegiline; N-Desmethylselegiline-d5; N-[(1R)-1-Methyl-2-phenylethyl]-N-methyl-2-propyn-1-amine-3,3,4,4,4-d5
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, isotopic purity (D-enrichment), and analytical results. We support compliance with GMP/GLP guidelines for research and regulatory purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (by NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.