Description

Melphalan-D8 Hydrochloride is a deuterated, isotopically labeled derivative of the alkylating chemotherapeutic agent Melphalan. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced cancer research and drug development.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a stable, isotopically labeled reference compound for the precise quantification of Melphalan in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of Melphalan metabolites using mass spectrometry.
• Method Development and Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for Melphalan drug substance and product.
• Biomedical Research: Supports fundamental research into the mechanisms of action, resistance, and toxicity of alkylating agents.

Basic Information

Product Name	Melphalan-D8 Hydrochloride
CAS No.	1217854-43-7
Molecular Formula	C13H10D8Cl2N2O2 • HCl
Molecular Weight	~ 341.7 g/mol
Synonyms	L-Phenylalanine mustard-D8 hydrochloride; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine-D8 hydrochloride; L-Sarcolysin-D8 hydrochloride; CB 3025-D8 hydrochloride; NSC-8806-D8 hydrochloride; Phenylalanine nitrogen mustard-D8 hydrochloride; Deuterated Melphalan HCl
EINECS	Contact for details

Quality Control

Our Melphalan-D8 Hydrochloride is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (HPLC), isotopic purity (NMR/MS), chemical purity, and residual solvent content. We adhere to relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.