Description

Didesmethyl Zolmitriptan-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based assays. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control departments for the precise bioanalysis and pharmacokinetic study of Zolmitriptan and its metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in Liquid Chromatography-Tandem Mass Spectrometry for the quantitative analysis of Zolmitriptan in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies for Zolmitriptan.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical and Pre-clinical Research: Facilitates precise measurement of drug and metabolite concentrations in plasma, serum, and other tissues during trials.
• Impurity Profiling and Characterization: Aids in the identification and quantification of related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Quality Control and Assurance: Supports high-accuracy testing in pharmaceutical QC labs to ensure batch consistency and purity of Zolmitriptan API.

Basic Information

Product Name	Didesmethyl Zolmitriptan-D4
CAS No.	1217853-52-5
Molecular Formula	C15H15D4N5O2
Molecular Weight	289.36 g/mol
Synonyms	Zolmitriptan Impurity D4; 4-[[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]methyl]-1,3-oxazolidin-2-one-d4; 3-[(2-Dimethylaminoethyl)-1H-indol-5-yl]methyl]-2-oxazolidinone-d4; Didemethyl Zolmitriptan D4; Zolmitriptan-d4 Didemethyl Metabolite; 311C88 Metabolite D4; (R)-Zolmitriptan N,N-Didesmethyl-D4
EINECS	Contact for details

Quality Control

Our Didesmethyl Zolmitriptan-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.