Description

Daunomycinone-13C,D3 is a stable isotope-labeled analog of the anthracycline aglycone daunomycinone, specifically enriched with carbon-13 and deuterium. This compound is a critical reference standard and metabolic tracer in pharmaceutical research and development, enabling precise pharmacokinetic and metabolic studies. It is essential for scientists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, isotopically labeled materials for advanced mass spectrometry, drug metabolism and pharmacokinetics (DMPK), and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-precision quantitative standard for the accurate measurement of daunomycinone and related anthracyclines in complex biological matrices.
• Drug Metabolism Studies (DMPK): Used as a tracer to elucidate metabolic pathways, identify metabolites, and study the biotransformation of anthracycline drugs in vitro and in vivo.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods for pharmacokinetic and toxicokinetic assessments.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Stable Isotope Labeling in Medicinal Chemistry: Used in the synthesis of labeled drug candidates to support mechanistic studies and intellectual property strategies.
• Clinical Research: Supports clinical trial studies requiring highly accurate tracking of drug disposition and clearance.

Basic Information

Product Name	Daunomycinone-13C,D3
CAS No.	1217837-48-3
Molecular Formula	C2113CH15D3O8
Molecular Weight	~ 414.37 g/mol (for major isotopologue)
Synonyms	(+)-Daunomycinone-13C,D3; 7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione-13C,D3; 8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione-13C,D3 (aglycone); Daunorubicinone-13C,D3; Isotopically Labeled Daunomycinone; [13C,D3]-Daunomycinone
EINECS	Contact for details

Quality Control

Our Daunomycinone-13C,D3 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., 13C & D atom %), chemical purity by HPLC, and identity confirmation by spectroscopic methods. We adhere to relevant industry standards for reference materials to support GLP and GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with labeled molecular ion pattern
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity	≥ 99 atom % 13C (at designated position) ≥ 98 atom % D (at designated positions)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.