Description

(+)-Manidipine-D4 CAS NO 1217836-12-8 is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based bioanalytical methods, particularly for pharmacokinetic and metabolism studies. It is primarily used by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and academic institutions developing or validating assays for the antihypertensive agent manidipine.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of manidipine in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development & Validation: Used as a reference compound to develop, optimize, and validate robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring and bioequivalence studies for manidipine and related pharmaceutical formulations.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of metabolites and potential degradants during drug stability testing.
• Forensic and Toxicology Analysis: Facilitates the accurate detection and measurement of manidipine in forensic investigations.

Basic Information

Item	Details
Product Name	(+)-Manidipine-D4
CAS No.	1217836-12-8
Molecular Formula	C35H34D4N2O6
Molecular Weight	582.71 g/mol (approx.)
Synonyms	Manidipine-d4; (+)-Manidipine-d4; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester-d4; CAS 1217836-12-8; Deuterated Manidipine; Manidipine Internal Standard; Manidipine-d4 Stable Isotope
EINECS	Contact for details

Quality Control

Every batch of (+)-Manidipine-D4 is manufactured and analyzed under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry to confirm chemical structure, isotopic enrichment (typically ≥98% D), and chromatographic purity. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each product to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.