Description

Ent-Calindol Amide is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel calcium-sensing receptor (CaSR) modulators, which are pivotal in developing treatments for bone and mineral disorders. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in metabolic disease research, osteoporosis drug discovery, and the development of calcimimetic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of calcimimetic drug candidates targeting the calcium-sensing receptor (CaSR).
• Research & Development: Used as a reference standard and building block in medicinal chemistry programs for metabolic and endocrine disorders.
• Drug Discovery: Integral component in the development of novel therapeutics for hyperparathyroidism, osteoporosis, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Biochemical Research: Employed in vitro studies to investigate CaSR signaling pathways and receptor-ligand interactions.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.

Basic Information

Product Name	Ent-Calindol Amide
CAS No.	1217835-51-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-N-((R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)prop-2-yn-1-amine; Enantiomer of Calindol Amide; (R,R)-Calindol Amide; CaSR Modulator Intermediate; Calcimimetic Intermediate
EINECS	Contact for details

Quality Control

Our Ent-Calindol Amide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.