Description

Boc-L-β-Homohydroxyproline(Obzl)-Dcha is a protected, non-proteinogenic amino acid derivative, specifically a homohydroxyproline analog, designed for advanced peptide synthesis and medicinal chemistry research. This high-purity building block is critical for introducing conformational constraints and enhancing the metabolic stability of novel peptide-based therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of peptide drugs, protease inhibitors, and other bioactive compounds. The product, identified by CAS number 1217832-67-1, offers reliable quality for sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Medicinal Chemistry Research: Used to incorporate homohydroxyproline motifs into novel drug candidates to study structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymes like collagenases or other metalloproteases.
• Conformationally Restricted Peptide Design: The homoproline ring structure introduces specific torsional angles, enabling the design of peptides with stabilized secondary structures.
• Bioconjugation and Labeling: The protected functional groups allow for selective deprotection and subsequent conjugation with labels, tags, or other molecular entities.
• Academic and Institutional Research: Employed in university and government labs for fundamental studies in organic synthesis and peptide science.

Basic Information

Item	Detail
Product Name	Boc-L-β-Homohydroxyproline(Obzl)-Dcha
CAS No.	1217832-67-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-(benzyloxy)-2-piperidinecarboxylic Acid Dicyclohexylamine Salt; Boc-4-(Obzl)-L-homoHyp-OH•DCHA; Boc-L-β-Homohydroxyproline(Obzl)-OH Dicyclohexylamine Salt; tert-Butoxycarbonyl-L-β-homohydroxyproline (benzyl ether) DCHA Salt; N-α-Boc-4-O-benzyl-L-homohydroxyproline Dicyclohexylammonium Salt; Protected L-Homohydroxyproline DCHA Salt; Boc-Hyp(4-OBzl)-OH•DCHA (homolog)
EINECS	Contact for details

Quality Control

Every batch of Boc-L-β-Homohydroxyproline(Obzl)-Dcha is produced and tested under a strict quality management system to ensure consistency and reliability for critical research and development applications. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is available for each lot upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.