Description

(2S)-4,4-Dimethyl-Pyroglutamic Acid CAS NO 1217832-12-6 is a high-purity, non-proteinogenic amino acid derivative characterized by its chiral (S)-configuration and a constrained pyrrolidone ring structure. This compound is a critical chiral building block and intermediate in organic synthesis, valued for its role in constructing complex molecules with defined stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide mimetics, protease inhibitors, and other bioactive molecules with potential therapeutic applications.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that require specific stereochemistry for optimal activity.
• Peptide Chemistry: Serves as a constrained proline analog for modifying peptide backbone structure, enhancing metabolic stability, and influencing secondary structure in peptide-based drug discovery.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to induce stereoselectivity in target molecules.
• Material Science: A potential monomer or precursor for synthesizing specialty polymers and functional materials with unique properties.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving glutaminyl cyclase or related enzymes.

Basic Information

Product Name	(2S)-4,4-Dimethyl-Pyroglutamic Acid
CAS No.	1217832-12-6
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(S)-4,4-Dimethyl-5-oxopyrrolidine-2-carboxylic Acid; (2S)-4,4-Dimethyl-5-oxo-D-proline; L-4,4-Dimethylpyroglutamic Acid; (S)-4,4-Dimethylpyroglutamic Acid; 4,4-Dimethyl-L-pyroglutamic Acid; (S)-(-)-4,4-Dimethyl-2-pyrrolidone-5-carboxylic Acid; (2S)-4,4-Dimethyl-2-pyrrolidinone-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (2S)-4,4-Dimethyl-Pyroglutamic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.