Description

Calindol-13C,D2 Hydrochloride is a high-purity, isotopically labeled derivative of the potent calcium-sensing receptor (CaSR) agonist, Calindol. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and academic institutions engaged in the development and analysis of calcimimetic drugs and related therapeutic agents.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Calindol and its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Stable Isotope Labeling Studies: Used in metabolic pathway elucidation and isotope dilution mass spectrometry to correct for analyte loss during sample preparation and ionization variability.
• Pharmaceutical R&D: Supports method development and validation for quality control and regulatory submissions (e.g., FDA, EMA) for calcimimetic drug candidates.
• Clinical Research: Facilitates reliable therapeutic drug monitoring (TDM) and biomarker analysis in clinical trials for disorders of calcium homeostasis.

Basic Information

Product Name	Calindol-13C,D2 Hydrochloride
CAS No.	1217828-76-6
Molecular Formula	C19H19D213CN2O•HCl
Molecular Weight	Contact for details
Synonyms	(R)-N-((1H-Indol-3-yl)methyl)-1-(1-naphthyl)ethanamine-13C,d2 Hydrochloride; (R)-1-(1-Naphthyl)-N-((1H-indol-3-yl)methyl)ethanamine-13C,d2 Hydrochloride; Calindol-13C,d2 HCl; [13C,d2]-Calindol Hydrochloride; Isotopically Labeled Calindol HCl; CaSR Agonist-13C,d2 Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Calindol-13C,D2 Hydrochloride is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with the high standards required for analytical reference materials. A comprehensive Certificate of Analysis (COA), detailing isotopic purity, chemical purity, and analytical results, is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C; ≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.