Description

Fmoc-(R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides, enabling the precise incorporation of a trifluoromethylphenyl side chain to modulate biological activity and physicochemical properties. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutics, particularly in the development of peptide-based drugs and protease inhibitors.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used to introduce the (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid residue into peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial chiral intermediate in the research and development of active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Protease Inhibitor Development: Used to construct peptide-mimetic scaffolds for inhibitors targeting various proteases, leveraging the unique electronic and steric properties of the trifluorophenyl group.
• Chemical Biology & Probe Synthesis: Employed in the synthesis of labeled peptides and activity-based probes for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality building block for the optimization and commercial-scale manufacturing of peptide therapeutics.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
CAS No.	1217818-53-5
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2,4,5-trifluorophenyl)-(R)-butyric Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid; Fmoc-D-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid; Fmoc-(R)-Amino(2,4,5-trifluorophenyl)butyric Acid; Fmoc-3-Amino-4-(2,4,5-trifluorophenyl)-(R)-butanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and HPLC for chemical purity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.