Description

Rac Threo-Dihydrobupropion-D9 is a deuterium-labeled isotopologue of a key metabolite of the antidepressant and smoking cessation aid bupropion. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug metabolism and pharmacodynamics (DMPK).

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled internal standard for the precise quantification of dihydrobupropion and related metabolites in biological matrices via liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of bupropion metabolite levels in plasma, serum, and urine to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioequivalence & Clinical Trials: Supports robust analytical data in clinical studies for generic drug development and formulation comparisons of bupropion-based medications.
• Forensic & Doping Control Analysis: Used in specialized toxicology screens to detect and quantify bupropion and its metabolites with definitive precision.
• Metabolite Reference Standard: Serves as a certified reference material for method development, validation, and quality control in analytical laboratories.

Basic Information

Product Name	Rac Threo-Dihydrobupropion-D9
CAS No.	1217815-08-1
Molecular Formula	C13H9D9ClNO
Molecular Weight	245.78 g/mol (for deuterated form)
Synonyms	(±)-Threo-Dihydrobupropion-D9; 2-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone-D9; (1RS,2SR)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-D9; Bupropion Metabolite D9; Dihydrobupropion-d9; THB-d9; Radiodetox D9 Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Rac Threo-Dihydrobupropion-D9 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to support your regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.