Description

Fmoc-D-Dab(Mtt)-Oh is a protected amino acid derivative, specifically an Fmoc-protected D-2,4-diaminobutyric acid (D-Dab) with a 4-methyltrityl (Mtt) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of the D-isomer of diaminobutyric acid into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of peptides containing D-2,4-diaminobutyric acid residues.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation: Serves as a precursor for creating peptide-based linkers and carriers for drug delivery systems, leveraging the orthogonal protection of the Mtt group.
• Chemical Biology: Employed in the synthesis of peptide probes and tools for studying protein-protein interactions and enzyme function.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing for clients worldwide.

Basic Information

Product Name	Fmoc-D-Dab(Mtt)-Oh
CAS No.	1217809-38-5
Molecular Formula	C₄₀H₃₆N₂O₄
Molecular Weight	596.73 g/mol
Synonyms	Fmoc-D-2,4-diaminobutyric acid(Mtt)-OH; N-α-Fmoc-N-δ-(4-methyltrityl)-D-2,4-diaminobutyric acid; Fmoc-D-Dab(4-Mtt)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[[4-methylphenyl(diphenyl)methyl]amino]butanoic acid; D-Dab(Mtt)-Fmoc; Fmoc-D-Dab(Mtt)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dab(Mtt)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment, ensuring full traceability and compliance with research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.