Description

n-Fmoc-5,5-Dimethyl-D-Norleucine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing sterically hindered, hydrophobic side chains with a chiral center, enabling the development of peptides with enhanced metabolic stability and specific conformational properties. It is an essential building block for pharmaceutical researchers and manufacturers focused on novel therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: For the development of active pharmaceutical ingredients (APIs) where enhanced lipophilicity and resistance to enzymatic degradation are required.
• Peptidomimetic Design: To create constrained peptide analogs and macrocycles by incorporating the bulky, gem-dimethyl substituted side chain.
• Bioconjugation: Useful in the synthesis of peptide-based linkers and carriers for drug delivery systems and antibody-drug conjugates (ADCs).
• Biochemical Probes: In the production of labeled peptides for studying protein-protein interactions and cellular signaling pathways.
• Combinatorial Chemistry: As a valuable scaffold in libraries for high-throughput screening to identify new lead compounds.

Basic Information

Product Name	n-Fmoc-5,5-Dimethyl-D-Norleucine
CAS No.	1217783-07-7
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-D-5,5-dimethylnorleucine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5,5-dimethylhexanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5,5-dimethyl-D-norleucine; Fmoc-D-Dimethylnorleucine-OH; Fmoc-D-2-Amino-5,5-dimethylhexanoic acid; D-Fmoc-5,5-dimethylnorleucine; N-α-Fmoc-5,5-dimethyl-D-norleucine
EINECS	Contact for details

Quality Control

Our n-Fmoc-5,5-Dimethyl-D-Norleucine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.