Description

Desthiazolylmethyloxycarbonyl Ritonavir-D6 is a deuterated analog of a key pharmaceutical intermediate, specifically designed for advanced research and development. This high-purity compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic studies of ritonavir and related compounds. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on drug metabolism, pharmacokinetics (PK/ADME), and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Critical for accurate LC-MS/MS quantification of ritonavir in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the metabolic pathways, bioavailability, and clearance of ritonavir.
• Pharmaceutical R&D: Serves as a key reference material in the development and validation of new analytical methods for antiviral drug formulations.
• Clinical Research: Supports therapeutic drug monitoring (TDM) studies and clinical trials involving protease inhibitor therapies.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly precise and accurate measurements due to its nearly identical chemical properties with the non-deuterated analyte.
• Quality Control & Assurance: Employed in GLP/GMP-compliant laboratories to ensure the accuracy and reliability of analytical data for regulatory submissions.

Basic Information

Product Name	Desthiazolylmethyloxycarbonyl Ritonavir-D6
CAS No.	1217772-02-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ritonavir D6 Intermediate; Deuterated Ritonavir Derivative; 5-Thiazolylmethyl [5S-(5R*,8R*,10R*,11R*)]-10-Hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oate-2H6; Desthiazolylmethyl Ritonavir-D6 Carboxylate; (Ritonavir-2H6) Desthiazolylmethyl Ester; Isotopically Labeled Ritonavir Standard
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality protocols to ensure the high isotopic purity and chemical stability required for sensitive analytical applications. Each batch is characterized using advanced techniques including NMR (1H, 13C) and High-Resolution Mass Spectrometry (HRMS). A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and storage recommendations. Our quality system supports compliance with GLP and ISO 17025 principles for research and regulatory work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Isotopic Purity (Atom % D)	≥98%
Chemical Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.