Description

(R)-4-Hydroxycarvedilol is a key chiral intermediate and an active metabolite of the β-blocker carvedilol. This compound is of significant importance for pharmaceutical research and development, particularly in the study of carvedilol's metabolism, stereoselective activity, and for the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development of cardiovascular drugs and analytical reference standards.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Metabolite Studies: Critical for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolic pathway and activity profile of carvedilol.
• Chiral Synthesis Building Block: Serves as a sophisticated intermediate in the asymmetric synthesis of novel β-adrenergic blocking agents or related chiral molecules.
• Active Pharmaceutical Ingredient (API) Impurity Profiling: Employed to identify, quantify, and control the (R)-4-hydroxy metabolite as a potential impurity in carvedilol API batches.
• Biochemical Research: Used in studies investigating the specific receptor binding affinities and stereochemical effects of carvedilol metabolites.

Basic Information

Product Name	(R)-4-Hydroxycarvedilol
CAS No.	1217770-29-0
Molecular Formula	C24H26N2O5
Molecular Weight	422.48 g/mol
Synonyms	(R)-4'-Hydroxycarvedilol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, (2R)-; 4'-Hydroxycarvedilol (R-enantiomer); Carvedilol Metabolite M14 (R-form); (2R)-1-(Carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol; UNII-5QK7R8F8Q5
EINECS	Contact for details

Quality Control

Our (R)-4-Hydroxycarvedilol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.