Description

(S)-Casodex-D4 CAS NO 1217769-79-3 is a deuterated isotopologue of the active pharmaceutical ingredient (S)-Bicalutamide, a non-steroidal anti-androgen. This high-purity reference standard is critical for ensuring analytical accuracy and regulatory compliance in pharmaceutical research and development. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for use as an internal standard in quantitative mass spectrometry, metabolism studies, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of (S)-Bicalutamide and its metabolites in complex biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track and analyze the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, FDA/EMA-compliant assays for clinical and pre-clinical trials.
• Stability-Indicating Assays: Employed in forced degradation studies to monitor the stability of the active pharmaceutical ingredient (API) under various stress conditions.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during API manufacturing.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and pharmacokinetic studies in oncology research, particularly for prostate cancer treatments.

Basic Information

Item	Detail
Product Name	(S)-Casodex-D4
CAS No.	1217769-79-3
Molecular Formula	C18H10D4F4N2O4S
Molecular Weight	430.40 g/mol
Synonyms	(S)-Bicalutamide-D4; (S)-Bicalutamide (phenyl-d4); N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-d4)sulfonyl]-2-hydroxy-2-methylpropanamide; (S)-Enantiomer of Bicalutamide-d4; Deuterated (S)-Casodex; (S)-Bicalutamide (phenyl ring-d4); Reference Standard (S)-Bicalutamide-D4
EINECS	Contact for details

Quality Control

Every batch of (S)-Casodex-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for certified reference materials (CRMs). A comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and residual solvents is provided with each shipment to ensure full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.