Description

(S)-α-(2-Furanylmethyl)-Proline is a high-purity, non-natural proline derivative featuring a chiral center and a furan ring moiety. This compound is a critical chiral building block and intermediate in modern pharmaceutical synthesis, enabling the development of novel therapeutics with enhanced efficacy and specificity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), particularly for complex small-molecule drugs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics Research: Used to construct peptide analogs where the proline scaffold is modified to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Ligand Development: Serves as a precursor for catalysts and chiral ligands in asymmetric catalysis, facilitating the production of enantiomerically pure compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds for potency and selectivity.
• Bioconjugation: The functional groups present make it suitable for conjugation strategies in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems.

Basic Information

Product Name	(S)-α-(2-Furanylmethyl)-Proline
CAS No.	1217753-90-6
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	(S)-α-(2-Furylmethyl)proline; (S)-2-[(Furan-2-yl)methyl]pyrrolidine-2-carboxylic acid; L-α-(2-Furanylmethyl)proline; (S)-2-(Furan-2-ylmethyl)proline; (2S)-2-[(Furan-2-yl)methyl]pyrrolidine-2-carboxylic acid; Furan-2-ylmethyl-L-proline; (S)-Proline, α-(2-furanylmethyl)-
EINECS	Contact for details

Quality Control

Our (S)-α-(2-Furanylmethyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.