Description

Rac trans-Paroxetine-D4 Hydrochloride CAS NO 1217753-24-6 is a deuterated isotopologue of the well-known selective serotonin reuptake inhibitor (SSRI), paroxetine, specifically labeled at four positions. This compound is a critical tool for pharmaceutical research and development, serving as an internal standard in quantitative bioanalytical methods such as LC-MS/MS. It is essential for scientists in pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories who require high-purity reference materials for pharmacokinetic studies, drug metabolism research, and ensuring regulatory compliance in assay validation.

Application

• Primary use as an internal standard for the accurate quantification of paroxetine in biological matrices via mass spectrometry.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies in preclinical and clinical research.
• Critical for method development and validation in bioanalytical laboratories to meet FDA, EMA, and ICH guidelines.
• Used in stable isotope dilution analysis to enhance the precision and accuracy of analytical results.
• Supports pharmaceutical impurity profiling and degradation studies.
• Enables forensic and toxicological analysis for the detection of paroxetine.

Basic Information

Product Name	Rac trans-Paroxetine-D4 Hydrochloride
CAS No.	1217753-24-6
Molecular Formula	C19H16D4FNO3 • HCl
Molecular Weight	373.85 g/mol (approx.)
Synonyms	Paroxetine-d4 Hydrochloride; (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-d4 Hydrochloride; trans-Paroxetine-d4 HCl; 6-Deuterio-5,7,8,14-tetradeuterioparoxetine Hydrochloride; (±)-trans-Paroxetine-d4 Hydrochloride; SSRIs-d4 internal standard; Paroxetine Isotopologue
EINECS	Contact for details

Quality Control

Every batch of our Rac trans-Paroxetine-D4 Hydrochloride is manufactured and tested to meet the stringent requirements for high-purity reference standards. We ensure compliance with relevant industry standards for isotopic purity and chemical purity. Comprehensive Certificates of Analysis (COA) are provided, detailing results for assay, isotopic enrichment, and impurity profiles by validated methods such as HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.