Description

Atorvastatin-D5 Lactone is a high-purity, deuterium-labeled internal standard specifically designed for quantitative bioanalytical applications. This compound is critical for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring precise measurement of atorvastatin and its metabolites.

Application

• Bioanalytical Method Development & Validation: Serves as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods.
• Pharmacokinetic (PK) Studies: Enables accurate quantification of atorvastatin and its active metabolites in biological matrices (plasma, serum, tissue).
• Drug Metabolism and Disposition (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track drug fate.
• Clinical Trial Support: Ensures data integrity in bioanalysis for Phase I-IV clinical trials involving atorvastatin.
• Forensic & Anti-Doping Analysis: Provides a reference for confirmatory testing in specialized analytical protocols.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability-indicating assays for atorvastatin drug substances and products.

Basic Information

Product Name	Atorvastatin-D5 Lactone
CAS No.	1217749-86-4
Molecular Formula	C33H30D5FN2O5
Molecular Weight	~ 562.66 g/mol
Synonyms	Atorvastatin-d5 Lactone; (3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid-d5 δ-Lactone; Atorvastatin Lactone-d5; Deuterated Atorvastatin Lactone; Atorvastatin-d5 (Lactone Form); [2H5]-Atorvastatin Lactone
EINECS	Contact for details

Quality Control

Every batch of Atorvastatin-D5 Lactone is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR (1H, 13C) and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic enrichment, and other critical specifications to meet the stringent requirements of analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.