Description

Boc-6-Chloro-D-Tryptophan CAS NO 1217738-82-3 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique structural and electronic properties of chlorinated tryptophan into peptide chains, enabling the development of novel bioactive molecules with enhanced stability or specific receptor interactions. It is an essential building block for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and fine chemical synthesis focused on creating peptide-based therapeutics, enzyme inhibitors, and molecular probes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel peptide-based drugs and therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a chlorinated tryptophan residue with a protected amine (Boc group).
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by modifying the indole ring of tryptophan to alter the biological activity and metabolic stability of lead compounds.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent or affinity probes targeting specific biological pathways.
• Enzyme Inhibitor Design: Used to develop inhibitors for enzymes that recognize tryptophan or its analogs, leveraging the chlorine atom for enhanced binding or selectivity.
• Academic & Industrial R&D: A valuable reagent for research institutions and CROs (Contract Research Organizations) exploring new chemical entities in drug discovery programs.

Basic Information

Product Name	Boc-6-Chloro-D-Tryptophan
CAS No.	1217738-82-3
Molecular Formula	C₁₆H₁₉ClN₂O₄
Molecular Weight	338.79 g/mol
Synonyms	(2R)-2-[(tert-Butoxycarbonyl)amino]-3-(6-chloro-1H-indol-3-yl)propanoic acid; D-Boc-6-Chlorotryptophan; N-Boc-6-Chloro-D-tryptophan; Boc-D-6-Chlorotryptophan; tert-Butyloxycarbonyl-6-chloro-D-tryptophan; N-(tert-Butoxycarbonyl)-6-chloro-D-tryptophan; 6-Chloro-D-tryptophan Boc derivative; Boc-6-Cl-D-Trp-OH
EINECS	Contact for details

Quality Control

Our Boc-6-Chloro-D-Tryptophan is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.