Description

Boc-(S)-3-Amino-3-(2-Furyl)-Propionic Acid CAS NO 1217736-81-6 is a high-purity, chiral amino acid derivative featuring a furan-protected side chain and a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control for advanced pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) to construct complex peptide sequences.
• Protease Inhibitor Development: Used in the design and synthesis of inhibitors targeting specific proteolytic enzymes, leveraging its unique furyl side chain for molecular recognition.
• Bioconjugation & Labeling: The reactive carboxylic acid and protected amine functionalities allow for site-specific conjugation in the development of antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Research: Employed as a tool compound to study protein-protein interactions and enzyme mechanisms due to its structural mimicry of natural amino acids.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for the optimization and commercial-scale manufacturing of peptide-based drugs.

Basic Information

Product Name	Boc-(S)-3-Amino-3-(2-Furyl)-Propionic Acid
CAS No.	1217736-81-6
Molecular Formula	C₁₂H₁₇NO₅
Molecular Weight	255.27 g/mol
Synonyms	(S)-3-((tert-Butoxycarbonyl)amino)-3-(furan-2-yl)propanoic acid; Boc-3-Amino-3-(2-furyl)propionic acid; (S)-Boc-3-Amino-3-(2-furyl)propanoic Acid; N-Boc-3-Amino-3-(2-furyl)propionic Acid; tert-Butyl (S)-(3-carboxy-1-(furan-2-yl)propyl)carbamate; (S)-2-((tert-Butoxycarbonyl)amino)-3-(furan-2-yl)propanoic acid; Boc-β-(2-Furyl)-L-alanine
EINECS	Contact for details

Quality Control

Our Boc-(S)-3-Amino-3-(2-Furyl)-Propionic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.