Description

(S)-Citalopram-D6 Oxalate is a high-purity, deuterium-labeled internal standard critical for precise bioanalytical quantification. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and other advanced analytical techniques, where it serves as an essential reference for the accurate measurement of its parent drug, citalopram, in complex biological matrices. It is an indispensable tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring.

Application

• LC-MS/MS Internal Standard: Primary application as a stable, isotopically labeled reference standard for the quantitative analysis of citalopram and its metabolites in plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Forensic & Clinical Toxicology: Used for the accurate determination of citalopram levels in cases of suspected overdose, compliance monitoring, or post-mortem investigations.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles to understand biotransformation pathways.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust, GLP-compliant analytical methods.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product quality assurance.

Basic Information

Item	Details
Product Name	(S)-Citalopram-D6 Oxalate
CAS No.	1217733-09-9
Molecular Formula	C23H15D6FN2O5
Molecular Weight	430.45 g/mol
Synonyms	(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D6 Oxalate; Escitalopram-D6 Oxalate; S-Citalopram-D6 Oxalate; Deuterated Escitalopram Oxalate; Citalopram D6 (S-enantiomer) Oxalate; Lexapro-D6 Oxalate; (S)-Citalopram Hexadeuterated Oxalate
EINECS	Contact for details

Quality Control

Every batch of (S)-Citalopram-D6 Oxalate is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and MS to confirm structure, enantiomeric excess, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment supports compliance with GMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.