Description

Fmoc-D-2-Amino-5-Phenyl-Pentanoic Acid CAS NO 1217731-48-0 is a high-purity, non-natural amino acid derivative featuring a side-chain benzyl group protected by an Fmoc (9-fluorenylmethoxycarbonyl) group on the α-amino nitrogen. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling precise control over sequence and stereochemistry. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected D-configuration amino acid, it is essential for incorporating specific chiral centers into peptide chains to modulate biological activity, stability, and pharmacokinetic properties.
• Pharmaceutical Research & Development: Serves as a key intermediate in the discovery and development of novel peptide-based drugs, including GLP-1 analogs, antimicrobial peptides, and hormone therapeutics.
• Peptidomimetic Design: Used to create modified peptide backbones and side-chains that mimic natural peptides but offer enhanced metabolic stability, oral bioavailability, and receptor selectivity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets to identify lead compounds.
• Bioconjugation and Probe Synthesis: The Fmoc-protected amine allows for selective deprotection and subsequent conjugation with fluorescent dyes, biotin, or other reporter molecules for creating diagnostic tools.
• Academic & Institutional Research: A fundamental reagent for studies in organic chemistry, biochemistry, and medicinal chemistry focused on peptide structure-activity relationships.

Basic Information

Item	Detail
Product Name	Fmoc-D-2-Amino-5-Phenyl-Pentanoic Acid
CAS No.	1217731-48-0
Molecular Formula	C₂₆H₂₅NO₄
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-D-homoPhe-OH; Fmoc-D-2-Amino-5-phenylvaleric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homophenylalanine; Fmoc-D-Homophenylalanine; Nα-Fmoc-D-homophenylalanine; D-Homophenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-2-Amino-5-Phenyl-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing specific results for assay, optical rotation, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Specific Optical Rotation	Contact for details
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.