Description

Fmoc-L-2,4-Dimethylphe CAS NO 1217728-65-8 is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring the precise incorporation of a sterically hindered, hydrophobic side chain into peptide sequences. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where structural modification is essential for activity and stability.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing the 2,4-dimethylphenylalanine residue into custom peptide chains.
• Pharmaceutical Research: For the discovery and development of novel peptide-based drugs, hormones, and enzyme inhibitors.
• Peptidomimetic Design: Used to create synthetic analogs of natural peptides with enhanced metabolic stability, bioavailability, or receptor selectivity.
• Bioconjugation: Serves as a specialized component in the synthesis of peptide-protein conjugates or peptide-labeled molecules for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A vital reagent in laboratories focused on organic chemistry, medicinal chemistry, and chemical biology for structure-activity relationship (SAR) studies.
• Production of Specialty Peptides: Enables the commercial-scale manufacturing of custom peptides for research, diagnostic, and preclinical development purposes.

Basic Information

Product Name	Fmoc-L-2,4-Dimethylphe
CAS No.	1217728-65-8
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-2,4-dimethyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,4-dimethyl-L-phenylalanine; Fmoc-Dmp-OH; Fmoc-L-(2,4-DiMe)Phe-OH; N-Fmoc-2,4-dimethyl-L-phenylalanine; Fmoc-2,4-Dimethylphenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(2,4-dimethylphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-2,4-Dimethylphe is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.