Description

n-Fmoc-3-Hydroxy-D-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical chiral building block for constructing complex peptides and peptidomimetics with enhanced stability and specific biological activity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutic agents, including peptide-based drugs and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptides, particularly those requiring the incorporation of the D-isomer of tyrosine or its derivatives.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of peptide-based drug candidates, hormone analogs, and enzyme inhibitors.
• Peptidomimetic Design: Serves as a scaffold for creating metabolically stable analogs of natural peptides with improved pharmacokinetic properties.
• Bioconjugation and Labeling: The Fmoc-protected amino group and phenolic hydroxyl group provide handles for site-specific conjugation with labels, tags, or other biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent for studies in organic chemistry, medicinal chemistry, and chemical biology focused on peptide structure and function.

Basic Information

Product Name	n-Fmoc-3-Hydroxy-D-Phenylalanine
CAS No.	1217724-28-1
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-D-3-Hydroxyphenylalanine; Fmoc-D-3-Hydroxy-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-D-phenylalanine; Fmoc-3-Hydroxy-D-Phe; Fmoc-D-Tyr(3-OH); D-3-Hydroxyphenylalanine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Hydroxy-D-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry-standard analytical methods to guarantee the integrity of this critical building block.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.