Description

R-(-)-Manidipine-D4 is a deuterium-labeled isotopologue of the calcium channel blocker manidipine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and precision in pharmacokinetic and metabolic studies, where distinguishing the analyte from endogenous compounds is essential. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and bioanalytical method validation.

Application

• Bioanalytical Internal Standard: Serves as a stable isotope-labeled internal standard for the accurate quantification of manidipine in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Essential for developing and validating robust, regulatory-compliant analytical methods in pharmaceutical R&D.
• Doping Control & Forensic Analysis: Used as a reference compound in forensic toxicology and sports anti-doping programs for the definitive identification of manidipine.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of manidipine-based pharmaceutical products.

Basic Information

Product Name	R-(-)-Manidipine-D4
CAS No.	1217718-54-1
Molecular Formula	C35H34D4N4O6
Molecular Weight	~610.71 g/mol
Synonyms	(R)-(-)-Manidipine-d4; (R)-Manidipine-d4; Deuterated Manidipine; Manidipine (R-enantiomer)-d4; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester-d4; CAS 1217718-54-1
EINECS	Contact for details

Quality Control

Every batch of R-(-)-Manidipine-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, MS, and HPLC. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and chromatographic profile is provided with each shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.