Description

trans-Carboxy Glimepiride-D5 is a stable isotope-labeled analog of the active metabolite of the anti-diabetic drug glimepiride. This high-purity reference standard is essential for precise quantitative analysis in pharmaceutical research and development. It is primarily used by analytical laboratories and pharmaceutical manufacturers for method development, validation, and bioanalytical studies, ensuring accurate pharmacokinetic and metabolic profiling.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the accurate quantification of glimepiride and its metabolites in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables reliable tracking and measurement of drug metabolism pathways in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used as a reference compound to develop, optimize, and validate robust analytical methods compliant with GLP and FDA/EMA guidelines.
• Pharmaceutical Quality Control (QC): Supports impurity profiling and assay verification of glimepiride in finished drug products and active pharmaceutical ingredients (APIs).
• Clinical Research: Facilitates therapeutic drug monitoring and bioavailability/bioequivalence studies in human trials.

Basic Information

Product Name	trans-Carboxy Glimepiride-D5
CAS No.	1217718-14-3
Molecular Formula	C24H29D5N3O5S
Molecular Weight	~ 494.62 g/mol
Synonyms	trans-2-[[4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-5-((methyl-d3)carbamoyl)-3a,4,5,6,7,7a-hexahydro-1H-isoindole-4-carboxylic Acid-d2; Glimepiride Carboxylic Acid Metabolite-d5; 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-((methyl-d3)carbamoyl)-4-carboxyhexahydroisoindole-d2; M-1 Metabolite of Glimepiride-d5
EINECS	Contact for details

Quality Control

Our trans-Carboxy Glimepiride-D5 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical identity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including HPLC, MS, and NMR. We adhere to relevant industry guidelines for reference standards to ensure data integrity and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.