Description

(R)-Felodipine-D5 CAS NO 1217716-73-8 is a deuterium-labeled isotopologue of the calcium channel blocker (R)-Felodipine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and precision in pharmacokinetic and bioanalytical studies, particularly those involving mass spectrometry. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring reliable quantification of the parent drug in complex biological matrices.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a stable, non-interfering internal standard for the accurate quantification of (R)-Felodipine in biological fluids (plasma, serum, urine) during drug metabolism and pharmacokinetics (DMPK) studies.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for regulatory submissions.
• Metabolite Profiling and Tracing: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based metabolite identification studies.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for the enantiomeric purity of Felodipine in active pharmaceutical ingredient (API) manufacturing.
• Clinical Research: Enables precise measurement of drug concentration in patient samples during clinical trials to establish dose-response relationships and safety profiles.

Basic Information

Product Name	(R)-Felodipine-D5
CAS No.	1217716-73-8
Molecular Formula	C18H14D5Cl2NO4
Molecular Weight	386.27 g/mol (approximate)
Synonyms	(R)-Felodipine-d5; (R)-3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate-d5; Deuterated (R)-Felodipine; (R)-Felodipine (phenyl-d5); (R)-Isradipine-d5 (related analog); (R)-H 154/82-d5; (R)-Plendil-d5 (labeled analog); (R)-Sagittol-d5
EINECS	Contact for details

Quality Control

Every batch of (R)-Felodipine-D5 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, isotopic enrichment, and confirm chemical identity and structure. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated bioanalysis, supporting compliance with GLP and GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). For long-term stability, storage at -20°C is recommended. The container should be kept in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.