Description

Boc-(S)-α-(3-Thiophenylmethyl)-Proline CAS NO 1217714-91-4 is a high-purity, non-natural amino acid derivative featuring a Boc-protected proline core with a chiral thiophene-containing side chain. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other advanced drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, non-natural amino acid residues that can modulate peptide conformation, stability, and biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies and high-throughput screening campaigns.
• Bioconjugation & Probe Development: The thiophene moiety can be leveraged for further functionalization or as a handle in the development of chemical probes and diagnostic agents.
• Academic & Industrial R&D: Essential for fundamental research in organic synthesis, asymmetric catalysis, and the study of peptidomimetics.

Basic Information

Product Name	Boc-(S)-α-(3-Thiophenylmethyl)-Proline
CAS No.	1217714-91-4
Molecular Formula	C16H21NO4S
Molecular Weight	323.41 g/mol
Synonyms	(S)-1-((tert-Butoxycarbonyl)-2-((3-thienyl)methyl)proline; (S)-1-Boc-2-((thiophen-3-yl)methyl)proline; Boc-S-3-Thienylmethyl-Proline-OH; tert-Butyl (2S)-2-[(thiophen-3-yl)methyl]pyrrolidine-1-carboxylate; N-Boc-3-(3-Thienyl)-L-alanine; (S)-1-(tert-Butoxycarbonyl)-2-(3-thienylmethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(3-Thiophenylmethyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.