Description

Phenylephrine D3 is a deuterium-labeled analog of the well-known α-1 adrenergic receptor agonist, phenylephrine. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing unmatched accuracy in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced analytical method development and drug metabolism research.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of phenylephrine in biological matrices.
• Critical for conducting pharmacokinetic (PK) and bioavailability studies of phenylephrine-containing drug formulations.
• Facilitates drug metabolism and disposition (DMPK) research, helping to elucidate metabolic pathways.
• Enables the development and validation of highly sensitive and specific bioanalytical assays in compliance with FDA and ICH guidelines.
• Supports clinical research by ensuring accurate measurement of drug concentrations in plasma, serum, and urine samples.
• Applied in forensic and toxicological analysis for the definitive identification and quantification of phenylephrine.

Basic Information

Product Name	Phenylephrine D3
CAS No.	1217705-88-8
Molecular Formula	C9H10D3NO2
Molecular Weight	169.22 g/mol (approx.)
Synonyms	(R)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol-d3; (R)-(-)-Phenylephrine-d3; L-Phenylephrine-d3; 1-(3-Hydroxyphenyl)-2-(methylamino)ethanol-d3; m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol-d3; Neo-Synephrine-d3; Metaoxedrine-d3; Isotopic Labeled Phenylephrine
EINECS	Contact for details

Quality Control

Our Phenylephrine D3 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-labeling), chemical purity by HPLC, and identity confirmation. We support research compliant with ICH, FDA, and other global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.