Description

Selegiline-D5/Deprenyl-D5 is a deuterated analog of the pharmaceutical compound Selegiline, where five hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This high-purity, isotopically labeled standard is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily used by research institutions, pharmaceutical developers, and contract testing laboratories engaged in pharmacokinetic studies, drug metabolism research, and the development of validated bioanalytical assays.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Selegiline and its metabolites in complex biological matrices using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a reference material to develop, optimize, and validate sensitive and specific analytical methods compliant with GLP and FDA guidelines.
• Drug Impurity Profiling and Stability Testing: Assists in identifying and quantifying potential deuterated impurities or degradation products in drug substance and product analysis.
• Forensic and Clinical Toxicology: Supports accurate measurement of Selegiline levels in forensic investigations or therapeutic drug monitoring programs.

Basic Information

Product Name	Selegiline-D5/Deprenyl-D5
CAS No.	1217705-21-9
Molecular Formula	C13H12D5N•HCl
Molecular Weight	223.78 g/mol (Hydrochloride salt)
Synonyms	(R)-(-)-Deprenyl-D5; (R)-N,α-Dimethyl-N-(2-propynyl)benzeneethanamine-D5; L-Deprenyl-D5; Jumex-D5; Eldepryl-D5; Selegiline Hydrochloride-D5; (R)-(-)-N,α-Dimethyl-N-2-propynylphenethylamine-D5 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Selegiline-D5/Deprenyl-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization including NMR, HPLC, and MS analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic enrichment, and other critical specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.