Description

Boc-(S)-α-(4-Cyano-Benzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a Boc-protected proline core and a chiral 4-cyanobenzyl side chain. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates, particularly for protease inhibitors and other bioactive molecules. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for protease-targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs with specific side-chain functionality.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile building block for creating compound libraries and optimizing lead structures in medicinal chemistry programs.
• Bioconjugation & Probe Development: The cyano group offers a handle for further chemical modification, useful in creating labeled probes or bioconjugates for biochemical studies.
• Catalyst & Ligand Development: Can be utilized in the design and synthesis of novel chiral catalysts or ligands for asymmetric synthesis.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	Boc-(S)-α-(4-Cyano-Benzyl)-Proline
CAS No.	1217698-68-4
Molecular Formula	C18H22N2O4
Molecular Weight	330.38 g/mol
Synonyms	(S)-1-((tert-Butoxycarbonyl)-2-((4-cyanobenzyl)methyl)proline; (S)-1-Boc-2-(4-cyanobenzyl)proline; Boc-S-α-(4-Cyanobenzyl)-Pro-OH; tert-Butyl (2S)-2-[(4-cyanophenyl)methyl]pyrrolidine-1-carboxylate; (S)-1-Boc-2-(4-Cyanobenzyl)-pyrrolidine-2-carboxylic Acid; N-Boc-(S)-α-(4-Cyanobenzyl)proline; (S)-N-Boc-2-(4-Cyanobenzyl)proline; Boc-(S)-A-(4-Cyano-Benzyl)-Pro-OH
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(4-Cyano-Benzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.