Description

Colchiceine-D3 is a deuterated analog of colchiceine, a key metabolite of the alkaloid colchicine, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical research.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of colchicine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Used to track drug metabolism and absorption rates in preclinical and clinical research.
• Forensic Toxicology: Supports accurate measurement of colchicine levels in forensic investigations and overdose cases.
• Drug Metabolism and Disposition (DMPK) Research: Aids in elucidating metabolic pathways and identifying metabolites.
• Quality Control in Pharmaceutical Manufacturing: Ensures batch consistency and purity of colchicine-based active pharmaceutical ingredients (APIs).
• Reference Standard for Method Validation: Critical for developing, validating, and complying with regulatory guidelines (e.g., FDA, EMA) for bioanalytical assays.

Basic Information

Product Name	Colchiceine-D3
CAS No.	1217695-72-1
Molecular Formula	C₂₁H₂₀D₃NO₆
Molecular Weight	374.40 g/mol
Synonyms	Colchiceine-d3; N-Deacetyl-N-(2,3,4-trimethoxybenzoyl)-colchicine-d3; 3-Demethylcolchicine-d3; (-)-Colchiceine-d3; Colchiceine (deuterated); Colchiceine Internal Standard; [2H3]-Colchiceine; N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]-2,3,4-trimethoxybenzamide-d3
EINECS	Contact for details

Quality Control

Every batch of Colchiceine-D3 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for assay, isotopic enrichment, and purity. We support compliance with cGMP and ICH guidelines for reference standards used in regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.