Description

S-(-)-Cotinine Perchlorate is a high-purity, enantiomerically pure chemical reference standard and synthetic intermediate. This compound is critical for analytical and pharmacological research, providing a definitive benchmark for the quantification and study of nicotine metabolites. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in toxicology, biomarker discovery, and metabolic pathway analysis.

Application

• Analytical Reference Standard: Primary standard for HPLC, LC-MS, and GC-MS quantification of cotinine and related alkaloids in biological matrices.
• Pharmacological Research: Key intermediate in the synthesis of novel nicotinic acetylcholine receptor (nAChR) ligands and for studying stereoselective metabolism.
• Clinical Toxicology: Calibrator for accurate measurement of tobacco smoke exposure and nicotine consumption in diagnostic assays.
• Biomarker Development: Used in the development and validation of immunoassays and biosensors for point-of-care testing.
• Metabolic Studies: Probe for investigating the enzymatic pathways and pharmacokinetics of nicotine derivatives.
• Pharmaceutical Impurity Profiling: Serves as a specified impurity standard in the quality control of smoking cessation therapeutics.

Basic Information

Product Name	S-(-)-Cotinine Perchlorate
CAS No.	1217692-15-3
Molecular Formula	C10H12N2O • HClO4
Molecular Weight	284.68 g/mol
Synonyms	(-)-Cotinine Perchlorate; (S)-(-)-Cotinine Perchlorate; L-Cotinine Perchlorate; (5S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone Perchlorate; Cotinine Perchlorate Salt; S-Cotinine Perchlorate; Nicotine Metabolite Perchlorate
EINECS	Contact for details

Quality Control

Our S-(-)-Cotinine Perchlorate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider under an inert atmosphere in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.