Description

4'-Hydroxy Atomoxetine-D3 is a deuterated isotopologue of the major human metabolite of atomoxetine, a selective norepinephrine reuptake inhibitor. This labeled compound is a critical reference standard and an essential tool for quantitative bioanalytical method development and validation in pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in drug metabolism and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of 4'-hydroxy atomoxetine and atomoxetine in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in metabolite profiling, pharmacokinetic studies, and mass balance investigations to understand the disposition of atomoxetine.
• Bioanalytical Method Development: Essential for developing and validating robust, sensitive, and specific HPLC-MS/MS or UPLC-MS/MS assays in compliance with FDA/EMA guidelines.
• Forensic and Clinical Toxicology: Enables accurate measurement of atomoxetine and its metabolite levels for therapeutic drug monitoring (TDM) or forensic casework.
• Reference Material for Quality Control: Acts as a certified reference material (CRM) to ensure the accuracy and reliability of analytical results in quality control laboratories.

Basic Information

Product Name	4'-Hydroxy Atomoxetine-D3
CAS No.	1217686-14-0
Molecular Formula	C17H18D3NO2
Molecular Weight	274.38 g/mol
Synonyms	Atomoxetine D3 Metabolite; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-D3-propan-1-amine 4'-Hydroxy Derivative; (R)-N-Methyl-3-(2-methylphenoxy)-3-(4-hydroxyphenyl)-D3-propylamine; 4'-Hydroxy (R)-Tomoxetine-D3; 4'-OH-Atomoxetine-D3; LY-139603-D3 Metabolite; Desmethyl Atomoxetine D3 Hydroxy Derivative.
EINECS	Contact for details

Quality Control

Our 4'-Hydroxy Atomoxetine-D3 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D3)	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.