Description

Rac Erythro Dihydrobupropion-D9 is a deuterated isotopologue of a key metabolite of the antidepressant and smoking cessation aid bupropion. This compound is of significant value as a high-purity internal standard for quantitative bioanalytical methods, ensuring precise and accurate measurement in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of bupropion and its metabolites in plasma, serum, and urine samples using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Bioequivalence Studies: Supports critical research into drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Forensic and Clinical Toxicology: Used in assays to determine drug concentrations for overdose cases or compliance monitoring.
• Drug Metabolism and Disposition Research: Aids in elucidating metabolic pathways and identifying circulating metabolites in preclinical and clinical development.
• Method Development and Validation: Serves as a stable, non-interfering reference compound for developing robust analytical protocols in compliance with GLP/GCP guidelines.

Basic Information

Product Name	Rac Erythro Dihydrobupropion-D9
CAS No.	1217684-77-9
Molecular Formula	C13H9D9ClNO
Molecular Weight	245.78 g/mol
Synonyms	(±)-Erythro-Dihydrobupropion-D9; 2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol-D9; (1RS,2SR)-2-(tert-Butylamino)-1-(3-chlorophenyl)-1-propanol-D9; Bupropion Metabolite Hydroxybupropion-D9; BW 306U-D9; Erythro Hydroxybupropion-D9; rac-Erythro-Dihydrobupropion-D9
EINECS	Contact for details

Quality Control

Every batch of Rac Erythro Dihydrobupropion-D9 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and the absence of significant impurities. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.