Description

(R)-α-Phenethyl-L-Proline-Hcl CAS NO 1217684-31-5 is a high-purity, non-natural amino acid derivative used as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly in the development of active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including protease inhibitors and other bioactive molecules.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity and specific stereochemistry into peptide backbones for drug discovery.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for enantioselective synthesis.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis: A starting material for the bespoke synthesis of more complex, proprietary compounds for clients in the life sciences sector.

Basic Information

Product Name	(R)-α-Phenethyl-L-Proline Hydrochloride
CAS No.	1217684-31-5
Molecular Formula	C14H20ClNO2
Molecular Weight	269.77 g/mol
Synonyms	(R)-α-Phenethyl-L-proline hydrochloride; (R)-1-[(R)-1-Phenylethyl]pyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 1-[(1R)-1-phenylethyl]-, hydrochloride (1:1); (R)-1-((R)-1-Phenylethyl)proline HCl; (R)-1-[(R)-α-Methylbenzyl]proline hydrochloride; (R,R)-Phenethylproline hydrochloride; (R)-AHP-HCl
EINECS	Contact for details

Quality Control

Every batch of (R)-α-Phenethyl-L-Proline-Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality protocol includes HPLC for assay and chiral purity, NMR for structural confirmation, and KF titration for water content. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support cGMP-compliant documentation for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.