Description

Rac-Paroxetine-D4 Hydrochloride CAS NO 1217683-35-6 is a deuterated isotopologue of the well-known selective serotonin reuptake inhibitor (SSRI) paroxetine, where four hydrogen atoms are replaced with deuterium. This deuteration makes it an invaluable internal standard for the precise quantification of paroxetine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for Bioanalysis: Serves as a critical, non-interfering reference compound for the accurate quantification of paroxetine in plasma, serum, and other biological samples via mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of paroxetine.
• Forensic and Clinical Toxicology: Enables reliable detection and measurement of paroxetine levels in forensic investigations or therapeutic drug monitoring.
• Pharmaceutical Quality Control: Supports analytical method development for the assay and impurity profiling of paroxetine in active pharmaceutical ingredient (API) and finished dosage forms.
• Isotope Dilution Mass Spectrometry (IDMS): Essential for high-precision measurements where maximum accuracy is required, minimizing matrix effects and instrumental variability.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex spectra.

Basic Information

Product Name	Rac-Paroxetine-D4 Hydrochloride
CAS No.	1217683-35-6
Molecular Formula	C19H16D4FNO3·HCl
Molecular Weight	373.85 g/mol (approx.)
Synonyms	Paroxetine-d4 Hydrochloride; (±)-Paroxetine-d4 HCl; (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-d4 Hydrochloride; 6-Deuterio-5,7,8,9-tetradeuterio-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride; SSRID4 Hydrochloride (as internal standard); Paxil-d4 HCl (common reference); BRL-29060-d4 HCl.
EINECS	Contact for details

Quality Control

Every batch of Rac-Paroxetine-D4 Hydrochloride is manufactured and analyzed under strict quality management protocols to ensure the highest standards of isotopic purity and chemical identity, which are critical for its use as an analytical standard. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as isotopic purity (D4 content), chemical purity, and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to ensure long-term stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.