Description

Fmoc-(+/-)-trans-2-Aminomethylcyclohexanol CAS NO 1217682-23-9 is a protected amino alcohol derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a scaffold for the controlled introduction of the aminomethylcyclohexanol moiety under standard Fmoc solid-phase peptide synthesis (SPPS) conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, peptidomimetics, and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in peptide and macrocyclic drug discovery.
• Peptide Synthesis: Used in Fmoc-based solid-phase peptide synthesis (SPPS) to incorporate the constrained trans-2-aminomethylcyclohexanol structure into peptide chains, influencing conformation and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and biological pathways.
• Material Science: Potential building block for functionalized polymers and dendrimers with specific chiral properties.

Basic Information

Product Name	Fmoc-(+/-)-trans-2-Aminomethylcyclohexanol
CAS No.	1217682-23-9
Molecular Formula	C23H27NO3
Molecular Weight	365.47 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-trans-2-(aminomethyl)cyclohexanol; Fmoc-trans-2-(Aminomethyl)cyclohexanol; 2-(((9H-Fluoren-9-ylmethoxy)carbonyl)aminomethyl)cyclohexan-1-ol; (1R,2R)- and (1S,2S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)aminomethyl)cyclohexan-1-ol (racemic); Fmoc-AMCH; trans-2-(Fmoc-aminomethyl)cyclohexanol
EINECS	Contact for details

Quality Control

Our Fmoc-(+/-)-trans-2-Aminomethylcyclohexanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99:1 trans/cis
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.