Description

(+)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole CAS NO 1217680-69-7 is a high-purity, deuterated chiral intermediate of significant value in advanced pharmaceutical research and development. Its primary importance lies in its role as a critical building block for the synthesis of novel, isotopically labeled drug candidates, enabling detailed metabolic and pharmacokinetic studies. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing next-generation therapeutics, particularly those focused on neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of deuterated drug molecules, enhancing metabolic stability and enabling drug discovery.
• Isotope Labeling: Used in the preparation of deuterium-labeled internal standards for accurate Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalysis.
• Metabolic Studies: Facilitates tracing and identification of drug metabolites in preclinical and clinical research due to its deuterium atoms.
• Neurological Research: Serves as a precursor in the development of potential therapeutics targeting complex neurological pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of specialty active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for cutting-edge organic chemistry and medicinal chemistry projects.

Basic Information

Item	Detail
Product Name	(+)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole
CAS No.	1217680-69-7
Molecular Formula	C₁₀H₁₃D₃N₃OS
Molecular Weight	229.33 g/mol
Synonyms	(+)-2-Amino-6-propionamido-D3-4,5,6,7-tetrahydro-1,3-benzothiazole; (6R)-2-Amino-6-[(2,2,2-trideuteriopropanoyl)amino]-4,5,6,7-tetrahydro-1,3-benzothiazole; 2-Amino-6-propionamido-D3-tetrahydrobenzothiazole; Deuterated Pramipexole Intermediate; (R)-2-Amino-6-propionamido-D3-THTB; 1217680-69-7; Pramipexole-d3 precursor
EINECS	Contact for details

Quality Control

Our (+)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as chemical purity, enantiomeric excess, and isotopic enrichment. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.