Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Chloro-4-Fluorophe CAS NO 1217680-33-5 is a specialized, high-purity protected amino acid derivative used as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise and efficient construction of complex peptide and small molecule structures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially in the fields of oncology, neurology, and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drug candidates and complex small molecule APIs.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc-based peptide synthesis protocols to incorporate the D-2-chloro-4-fluorophenylalanine residue, which can modulate peptide stability, activity, and receptor binding.
• Proteomics Research: Employed in the design and synthesis of substrate analogs, enzyme inhibitors, and activity-based probes to study biological pathways.
• Antibody-Drug Conjugate (ADC) Development: Serves as a component in constructing specialized linker-payload systems for targeted cancer therapies.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of scalable synthetic routes for GMP manufacturing of clinical trial materials.
• Chemical Biology Tool Development: Incorporated into peptides and peptidomimetics to investigate protein-protein interactions and cellular signaling.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Chloro-4-Fluorophe
CAS No.	1217680-33-5
Molecular Formula	C24H19ClFNO4
Molecular Weight	439.86 g/mol
Synonyms	Fmoc-D-2-Chloro-4-fluorophenylalanine; Fmoc-D-Cl-F-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-chloro-4-fluorophenylalanine; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(2-chloro-4-fluorophenyl)propanoic acid; Fmoc-D-2-Cl-4-F-Phe; N-Fmoc-D-2-chloro-4-fluorophenylalanine; Fmoc-D-(2-Cl,4-F)Phe; Fmoc-D-2-chloro-4-fluoro-Phe
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Chloro-4-Fluorophe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) for long-term storage or after opening to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.