Description

(R)-Citalopram-D6 n-Oxide is a deuterium-labeled metabolite of the selective serotonin reuptake inhibitor (SSRI) citalopram. This compound is of significant value as a high-purity internal standard for quantitative bioanalytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug metabolism and forensic toxicology.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Critical for quantitative bioanalysis of citalopram and its metabolites in biological matrices such as plasma, serum, and urine.
• Enabling pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and drug development.
• Supporting forensic and clinical toxicology testing for accurate quantification of citalopram exposure.
• Facilitating drug metabolism and disposition (DMPK) research to understand metabolic pathways.
• Used in the development and validation of regulatory-compliant analytical methods for pharmaceutical quality control.

Basic Information

Product Name	(R)-Citalopram-D6 n-Oxide
CAS No.	1217669-62-9
Molecular Formula	C20H15D6FN2O2
Molecular Weight	334.42 g/mol
Synonyms	(R)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D6 N-Oxide; (R)-Citalopram N-Oxide-D6; (R)-Citalopram-D6 N-Oxide; 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile-D6 N-Oxide, (R)-; Deuterated Citalopram N-Oxide (R-enantiomer); Citalopram-D6 N-Oxide (R)-Form
EINECS	Contact for details

Quality Control

Our (R)-Citalopram-D6 n-Oxide is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical data is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D6)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.