Description

5'-Des-o-Methylhomoharringtonine-13C,D3 is a stable isotope-labeled analog of a homoharringtonine derivative, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity reference material is critical for ensuring accurate and reliable quantification in complex biological matrices, such as plasma or tissue samples. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in pharmacokinetic, metabolic, and clinical studies related to cephalotaxine alkaloids.

Application

• Quantitative Bioanalysis: Serves as an essential internal standard for the precise measurement of homoharringtonine and related analogs in biological fluids using LC-MS/MS and HPLC methods.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for research and development programs.
• Metabolite Identification & Profiling: Aids in the detection and characterization of drug metabolites in preclinical and clinical studies.
• Method Development & Validation: Provides a stable, isotopically distinct reference for developing and validating robust analytical assays in compliance with GLP/GCP guidelines.
• Clinical Trial Support: Used in bioanalytical testing to support clinical trials for oncology therapeutics derived from or related to cephalotaxus alkaloids.
• Quality Control in Manufacturing: Can be employed as a reference standard for the quality control of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	5'-Des-o-Methylhomoharringtonine-13C,D3
CAS No.	1217669-36-7
Molecular Formula	C28H35NO9 (with 13C and D3 labeling)
Molecular Weight	Contact for details
Synonyms	5'-Des-O-methylhomoharringtonine-13C,D3; Isotopically Labeled 5'-Des-O-methylhomoharringtonine; 13C,D3-5'-Des-O-methylhomoharringtonine; Harringtonine Derivative-13C,D3; Cephalotaxine Alkaloid Internal Standard; 5'-Des-O-methylhomoharringtonine (13C,D3 labeled); (3'R)-5'-Des-O-methylhomoharringtonine-13C,D3
EINECS	Contact for details

Quality Control

Every batch of 5'-Des-o-Methylhomoharringtonine-13C,D3 is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with the high-purity standards required for analytical reference materials. Certificates of Analysis (COA) are provided, detailing isotopic purity, chemical purity, and confirming structural identity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 98%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.