Description

Ropivacaine-D7 Hydrochloride is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in modern bioanalytical research. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists requiring definitive reference materials for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the bioanalysis of Ropivacaine and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to understand absorption, distribution, metabolism, and excretion (ADME).
• Drug Metabolism Studies: Facilitates the identification and quantification of metabolite formation using stable isotope dilution techniques.
• Method Development & Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Forensic & Clinical Toxicology: Applied in assays for monitoring Ropivacaine levels in cases of anesthesia management or suspected toxicity.
• Quality Control in Pharmaceutical Manufacturing: Used in in-process testing and stability studies to ensure product consistency and purity.

Basic Information

Product Name	Ropivacaine-D7 Hydrochloride
CAS No.	1217667-10-1
Molecular Formula	C17H19D7N2O•HCl
Molecular Weight	328.90 g/mol (approx.)
Synonyms	(S)-(-)-1-Propyl-2',6'-pipecoloxylidide-d7 Hydrochloride; (S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide-d7 Hydrochloride; Ropivacaine-d7 HCl; Ropivacaine (methyl-d7) Hydrochloride; Naropin-d7 Hydrochloride; LE-103-d7 Hydrochloride; 1-Propyl-2',6'-pipecoloxylidide-d7 Monohydrochloride
EINECS	Contact for details

Quality Control

Every batch of Ropivacaine-D7 Hydrochloride is manufactured and analyzed under strict quality management systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.