Description

Fmoc-3-(Boc-Aminomethyl)-D-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide orthogonal protection for both the α-amino and side-chain amino groups, enabling precise, sequential deprotection strategies in complex peptide assembly. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and novel biomaterials that require high structural fidelity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of a modified phenylalanine residue with a protected aminomethyl side chain.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs, including antimicrobial peptides, hormone analogs, and targeted cancer therapies.
• Peptidomimetic Design: Serves as a scaffold for creating stable peptide mimics with enhanced bioavailability and metabolic stability.
• Chemical Biology Probes: Enables the site-specific introduction of functional handles or labels into peptides for studying protein-protein interactions.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• GPCR Ligand Development: Applied in the synthesis of peptide ligands for G-protein-coupled receptors, a major drug target class.

Basic Information

Product Name	Fmoc-3-(Boc-Aminomethyl)-D-Phenylalanine
CAS No.	1217665-54-7
Molecular Formula	C31H34N2O6
Molecular Weight	530.61 g/mol
Synonyms	Fmoc-D-Phe(3-NHBoc-CH2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-D-phenylalanine; Fmoc-3-(N-Boc-aminomethyl)-D-phenylalanine; Boc-NH-CH2-D-Phe(3)-OH-Fmoc; D-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; Fmoc-D-3-(Boc-Aminomethyl)Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3-(Boc-Aminomethyl)-D-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis to confirm the D-configuration, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.