Description

Amprenavir-D4 CAS NO 1217661-20-5 is a deuterated analog of the antiretroviral drug Amprenavir, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard in quantitative bioanalytical research, ensuring the accuracy and reliability of pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of HIV protease inhibitors.

Application

• Bioanalytical Reference Standard: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Amprenavir and its metabolites in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry-based assays to track drug absorption, distribution, metabolism, and excretion (ADME) with high specificity, correcting for matrix effects and instrument variability.
• Pharmaceutical Impurity Profiling: Employed as a marker in analytical method development to identify and quantify process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Clinical Research: Facilitates accurate therapeutic drug monitoring (TDM) in clinical trials to establish dose-response relationships and ensure patient safety.
• Forensic and Anti-Doping Analysis: Acts as a definitive standard in confirmatory testing protocols where high analytical certainty is required.

Basic Information

Product Name	Amprenavir-D4
CAS No.	1217661-20-5
Molecular Formula	C25H31D4N3O3S
Molecular Weight	~ 469.65 g/mol
Synonyms	AG1776-D4; VX-478-D4; (3S)-Tetrahydro-3-furyl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propylcarbamate-D4; [4-Amino-N-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-aminophenyl)sulfonamido)-1-phenylbutan-2-yl)-3-(tetrahydrofuran-3-yloxy)benzamide]-D4; Amprenavir-d4; Deuterated Amprenavir (4-D)
EINECS	Contact for details

Quality Control

Every batch of Amprenavir-D4 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing isotopic purity, chemical purity, and analytical results, is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.