Description

Rel-(R,S)-Voriconazole-D3 is a deuterated isotopologue of the broad-spectrum triazole antifungal agent voriconazole, specifically labeled with three deuterium atoms. This compound is an essential reference standard and internal standard for the precise quantification and pharmacokinetic studies of voriconazole in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in bioanalytical method development, drug metabolism and pharmacokinetics (DMPK) research, and clinical trial support.

Application

• Bioanalytical Reference Standard: Serves as a critical internal standard for the accurate and sensitive quantification of voriconazole in plasma, serum, and other biological fluids via mass spectrometry.
• Pharmacokinetic & DMPK Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Used to develop, optimize, and validate robust LC-MS/MS methods for therapeutic drug monitoring (TDM) and regulatory submissions.
• Metabolite Identification: Aids in the identification and characterization of voriconazole metabolites in complex biological samples.
• Quality Control in Manufacturing: Employed in the quality control of voriconazole active pharmaceutical ingredient (API) and finished drug products for impurity profiling.
• Forensic & Anti-Doping Analysis: Utilized as a certified reference material in forensic toxicology and sports anti-doping controls for definitive identification.

Basic Information

Product Name	Rel-(R,S)-Voriconazole-D3
CAS No.	1217661-14-7
Molecular Formula	C16H11D3F3N5O
Molecular Weight	352.33 g/mol
Synonyms	(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol-D3; Voriconazole-d3; Voriconazole (D3); (R,S)-Voriconazole-D3; (±)-Voriconazole-D3; UK-109496-d3; Deuterated Voriconazole; Voriconazole Internal Standard
EINECS	Contact for details

Quality Control

Our Rel-(R,S)-Voriconazole-D3 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (D-content), and identity confirmation (by NMR and MS). We adhere to relevant industry guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.