Description

2-{2-[(2S,5S)-2,5-Diethyl-1-Phospholano]Phenyl}1,3-Dioxolane, Min. 97% is a high-purity, chiral phosphine ligand of significant importance in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates and active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for complex synthetic routes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and alcohols.
• Critical component in transition metal catalysis (e.g., with Rh, Ru, Ir) for constructing chiral centers in complex pharmaceutical intermediates.
• Use in asymmetric C-C bond forming reactions, such as cross-coupling and allylic alkylation, to create valuable chiral building blocks.
• Development and optimization of industrial-scale catalytic processes for the production of agrochemicals and specialty chemicals.
• Research and development of novel catalytic systems in academic and industrial laboratories.
• Potential application in the synthesis of chiral ligands and catalysts for further catalytic exploration.

Basic Information

Product Name	2-{2-[(2S,5S)-2,5-Diethyl-1-Phospholano]Phenyl}1,3-Dioxolane, Min. 97%
CAS No.	1217655-83-8
Molecular Formula	C₁₇H₂₅O₂P
Molecular Weight	292.35 g/mol
Synonyms	(2S,5S)-2,5-Diethyl-1-[2-(1,3-dioxolan-2-yl)phenyl]phospholane; (S,S)-2,5-Diethyl-1-[2-(1,3-dioxolan-2-yl)phenyl]phospholane; (S,S)-DiEt-Phospholane-Dioxolane Ligand; (S,S)-Diethyl-Phospholane Phenyl Dioxolane; Dioxolane-Functionalized Chiral Phospholane Ligand; Asymmetric Hydrogenation Ligand; Chiral Bidentate Phosphine Ligand; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-{2-[(2S,5S)-2,5-Diethyl-1-Phospholano]Phenyl}1,3-Dioxolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity, which is paramount for catalytic performance. Each lot is analyzed to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing comprehensive test results, including assay by HPLC and chiral purity analysis, are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.