Description

n-Fmoc-3-(R)-Amino-2-(R)-Hydroxy-3-Naphthalen-2-Yl-Propionic Acid CAS NO 1217655-36-1 is a sophisticated, non-proteinogenic amino acid derivative featuring a stereochemically defined β-hydroxy-α-amino acid scaffold with a naphthyl side chain, protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical high-purity building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise introduction of constrained, hydrophobic structural motifs. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology developing novel therapeutic agents, diagnostic probes, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental monomer for the automated synthesis of peptides containing constrained β-hydroxy-α-amino acid residues.
• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of potential drug candidates, particularly for oncology, metabolic diseases, and infectious diseases.
• Peptidomimetic Design: Used to create peptide analogs with enhanced metabolic stability, bioavailability, and target specificity by incorporating rigid, aromatic structural elements.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Material Science: Can be incorporated into specialty polymers and self-assembling materials to impart specific chiral and hydrophobic properties.

Basic Information

Product Name	n-Fmoc-3-(R)-Amino-2-(R)-Hydroxy-3-Naphthalen-2-Yl-Propionic Acid
CAS No.	1217655-36-1
Molecular Formula	C29H25NO5
Molecular Weight	467.52 g/mol
Synonyms	Fmoc-3-(R)-Amino-2-(R)-hydroxy-3-(naphthalen-2-yl)propanoic Acid; Fmoc-β-HomoPhe(2-Nal)-OH; Fmoc-(2R,3R)-2-Hydroxy-3-amino-3-(naphthalen-2-yl)propionic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-hydroxy-3-(2-naphthyl)propanoic Acid; (2R,3R)-2-Hydroxy-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(naphthalen-2-yl)propanoic Acid; Fmoc-AHP(2-Nal)-OH; Fmoc-D-β-Homo-2-Nal-OH (β-hydroxy); Fmoc-protected β-hydroxy-2-naphthylalanine
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity, meeting the exacting standards required for pharmaceutical research and development. Standard testing includes HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.