Description

Colchicine-D6 is a stable isotope-labeled analog of the natural alkaloid colchicine, where six hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors requiring precise internal standards for method development and validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in bioanalytical method development for colchicine pharmacokinetic and metabolomic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying the parent drug and its metabolites in biological matrices (plasma, urine, tissue).
• Pharmaceutical Quality Control: Employed in the assay and impurity profiling of colchicine-based drug substances and finished products.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial bioanalysis for drugs containing colchicine.
• Forensic and Anti-Doping Analysis: Serves as a reference compound in confirmatory testing for colchicine in forensic toxicology and sports doping control.
• Stable Isotope Labeling Studies: Used in mechanistic studies to investigate metabolic pathways and degradation products.

Basic Information

Product Name	Colchicine-D6
CAS No.	1217651-73-4
Molecular Formula	C22H19D6NO6
Molecular Weight	405.45 g/mol
Synonyms	Colchicine-d6; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide-d6; Deuterated Colchicine; Colchicine (hexadeuterated); Colchicine Internal Standard; Colchicine-D6 Isotope; Colchicine (D6, 98%)
EINECS	Contact for details

Quality Control

Every batch of Colchicine-D6 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for isotopic purity and chemical identity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.